Benzinga | Nov 12, 2020 05:17AM EST

Kodiak Sciences Announced Presentation of KSI-301 Phase 1b Clinical Study Data Focused on Diabetic Macular Edema at American Academy of Ophthalmology 2020 Virtual Meeting

Kodiak Sciences Inc. (NASDAQ:KOD) announced that a pre-recorded presentation of clinical study data on its investigational therapy KSI-301 is available at the American Academy of Ophthalmology (AAO) 2020 Virtual Annual Meeting.

Details of the presentation are as follows:

Event: Late Breaking Developments, Part II

Title: One Year and Beyond: Long-term Multiple-dose Study of KSI-301, an Anti-VEGF Antibody Biopolymer Conjugate with Extended Durability, in wAMD, DME, and RVO

Presenter: Arshad M Khanani, M.D., M.A., managing partner and director of clinical research, Sierra Eye Associates, clinical associate professor of ophthalmology, University of Nevada

Presentation date and time: The pre-recorded presentation containing slides and audio will be available to AAO 2020 Virtual attendees starting on Wednesday, November 11. The presentation slides are also available on the "Events and Presentations" section of Kodiak's website at http://ir.kodiak.com/.

"As diabetic eye disease remains the leading cause of new blindness in working-aged Americans, and we recently started enrolling our GLEAM and GLIMMER pivotal studies in patients with Diabetic Macular Edema, Dr. Khanani's presentation at the AAO late-breaking session focuses on DME. The data suggest a transformative effect that allows for a combination of strong efficacy and remarkable durability. The results are out of the ordinary when benchmarked to current anti-VEGF agents," said Jason Ehrlich, M.D., Ph.D., Chief Medical & Development Officer of Kodiak Sciences. "We also remain very pleased with the safety profile of KSI-301, and the most recent Phase 1b safety data are reflected in Dr. Khanani's presentation. To date, KSI-301 has been administered more than 1,500 times to more than 400 patients across the entire development program, representing more than 250 patient-years of clinical experience. The presentation also refreshes the durability proportions of Phase 1b wet AMD and DME patients who achieved a 6 months or longer treatment-free interval during follow-up and RVO patients who achieved a 4 months or longer treatment-free interval during follow-up."

"Today's presentation provides perspectives on KSI-301's emerging efficacy and durability with an emphasis on helping the audience to understand and link the strong performance of KSI-301 to its precision engineering and underlying scientific rationale," said Victor Perlroth, M.D., Chief Executive Officer. "Today's presentation also includes new case examples showing long-term disease modification in diabetic macular edema and proliferative diabetic retinopathy patients with no or very few retreatments in treatment nave patients following only three loading doses. Given the unsustainable treatment burden of current anti-VEGFs, the unmet need for longer-lasting treatment of diabetic eye disease is clear, and confirmation of KSI-301's durability, efficacy and safety profile in GLEAM and GLIMMER would be an important advance for patients and physicians."