Benzinga | Dec 21, 2020 08:49AM EST

Kindred Biosciences Announces Positive Results from Pilot Field Effectiveness Study for Anti-TNF Antibody for Canine Inflammatory Bowel Disease

Kindred Biosciences, Inc. (NASDAQ:KIN), a biopharmaceutical company focused on saving and improving the lives of pets, today announced positive results from the pilot field effectiveness study of its monoclonal antibody against tumour necrosis factor alpha (anti-TNF? antibody) for canine inflammatory bowel disease (IBD).



The study was a randomized, blinded, placebo-controlled pilot effectiveness study that enrolled 10 dogs diagnosed with IBD to assess the efficacy and safety of KindredBio's anti-TNF? antibody over a 4-week treatment period. The primary effectiveness variable for this exploratory study was reduction in Canine Inflammatory Bowel Disease Activity Index (CIBDAI) score, which was assessed at Screening and Days 0, 7, 14, 21 and 28. Complete remission, defined as ? 75% reduction in average post-dose CIBDAI score from baseline, was achieved in 75% of the anti-TNF? group compared to 17% in the placebo group. The treatment effect was early-onset and durable. At Day 7, the first post-dose visit, 75% of the anti-TNF? treated dogs showed ? 75% reduction of CIBDAI score from baseline, compared to 17% in the placebo group. Furthermore, 50% of the anti-TNF? treated dogs achieved and maintained 100% reduction of CIBDAI score from baseline throughout all post-dose visits, whereas none in the placebo group achieved the same result.

"We are pleased to have observed a positive signal from this study, which marks the latest in a string of positive study results for our biologics candidates," said KindredBio's Chief Executive Officer, Richard Chin, M.D. "Gastrointestinal disease, which is often immune-mediated, is one of the most common diseases in dogs, and is an important unmet need, because existing treatments are often poorly effective and can have safety liabilities. Given the rapid and pronounced effect of this product candidate, we believe that it could become a very successful therapeutic."

The majority of canine IBD cases involve chronic states of diarrhea, vomiting, gastroenteritis, inappetence, and other symptoms. For certain dog breeds, the prevalence of diarrhea exceeds 5%.