Benzinga | Nov 13, 2020 08:32AM EST

Horizon Therapeutics Highlights Presentation Of TEPEZZA Data At American Academy Of Ophthalmology Annual Meeting



-- Presentation during American Academy of Ophthalmology Annual Meeting (AAO 2020 Virtual) demonstrates clinical improvement in the less severe eye --

-- Additional data from OPTIC 48-week follow-up study and OPTIC-X extension trial, including findings showing that the majority of TEPEZZA patients who were diplopia (double vision) responders in OPTIC at week 24 maintained their response at week 72, nearly a year off-treatment --

-- Patients who received placebo during the OPTIC Phase 3 clinical trial and then received TEPEZZA in the OPTIC-X extension trial also achieved clinically significant diplopia improvement with an average of 12 months of disease, compared with six months in OPTIC --

DUBLIN--(BUSINESS WIRE)-- Horizon Therapeutics plc (NASDAQ:HZNP) today announced new TEPEZZA(r) (teprotumumab-trbw) data presented at the American Academy of Ophthalmology Annual Meeting (AAO 2020 Virtual), including findings suggesting benefits of TEPEZZA in the less severe eye of patients with Thyroid Eye Disease (TED), and new data from the OPTIC 48-week follow-up study and OPTIC-X clinical trial. TEPEZZA is the first and only medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of TED -- a serious, progressive and vision-threatening rare autoimmune disease.1

"We continue to analyze our existing clinical trials and pursue new research to fully understand the impact TEPEZZA has on this challenging disease," said Elizabeth H.Z. Thompson, Ph.D., group vice president, development and external search, Horizon. "Our data demonstrating the effect of TEPEZZA at varying stages of the disease, including in the less severely affected eye and in patients who have had Thyroid Eye Disease for a longer period of time, will help advance the science of Thyroid Eye Disease and instill greater understanding of the role TEPEZZA can play in improving patient outcomes."