GlobeNewswire Inc | Jan 31, 2022 04:05PM EST

January 31, 2022

SOUTH SAN FRANCISCO, Calif., Jan. 31, 2022 (GLOBE NEWSWIRE) -- Lyell Immunopharma, Inc., (Nasdaq: LYEL), a T-cell reprogramming company dedicated to the mastery of T cells to cure patients with solid tumors, today announced the appointment of Gary Lee, Ph.D., as Chief Scientific Officer. A veteran biotech leader with more than a decade of experience heading translational cell and gene therapy programs, Dr. Lee will set and oversee the companys research strategy and advance its research pipeline.

We are thrilled to welcome Gary and his scientific expertise in translational cell therapy to the Lyell team, said Liz Homans, Chief Executive Officer of Lyell. Beyond his exceptional scientific talent, Gary brings tremendous leadership and strategic planning capabilities to our team. As we become a clinical-stage company, his appointment reflects our deeply held commitment to advancing a multi-modality cell therapy pipeline based on our novel next-generation T-cell reprogramming technologies.

Im excited to join the dynamic Lyell team and look forward to furthering the goal of delivering better therapeutic options for patients with solid tumors by advancing what I believe is one of the most promising pipelines in the industry, said Dr. Lee. Lyell is unique in many respects, includingarobust pipelineofCAR, TIL and TCR product candidatesthat incorporatenovel reprogramming technologies designed to overcome T-cell exhaustion and promote durable stemness. Ilook forward to working with this team of industry-leading experts in oncology and cell therapy drug development.

Before joining Lyell, Dr. Lee served as Chief Scientific Officer at Senti Bio. Prior to that he held scientific and leadership positions of increasing responsibility at Sangamo Therapeutics. As Sangamos Vice President of Cell Therapy, Dr. Lee led the companys T-cell engineering programs. Dr. Lee holds a Ph.D. in chemical engineering from the University of California, Berkeley, and a B.S. in chemical engineering from the California Institute of Technology.

Lyell also announced today that Dr. Nick Restifo, Executive Vice President, Research, will transition to a role as scientific advisor effective February 15, 2022. Dr. Restifo will continue to provide scientific insight on Lyells programs and research pipeline, with a particular focus on its Epi-R and Rejuvenation platforms.

Being a part of Lyells growth has been a rewarding professional opportunity, said Dr. Restifo. With an exceptional research organization firmly established, I look forward to working with Gary, continuing my close relationship with the team, and contributing to the future success of Lyell in my new role.

We are delighted to welcome a scientist of Garys caliber and deep industry experience to Lyell, said Rick Klausner, MD, Chair of Lyell's Board of Directors. His experience leading translational research of next generation cell therapies is particularly relevant as we enter our next stage of growth and on behalf of the Board of Directors, we welcome this key addition to our executive team. We also extend our gratitude to Nick for his innovative scientific contributions and look forward to continuing to benefit from his expertise as he transitions into a scientific advisory role.

About Lyell Immunopharma, Inc.

Lyell is a T-cell reprogramming company dedicated to the mastery of T cells to cure patients with solid tumors. The Company focuses on addressing what it believes are the primary barriers that limit consistent, reliable, and curative responses to adoptive T-cell therapy: T-cell exhaustion and lack of durable stemness, which includes proliferative capacity and the ability to self-renew, differentiate and eliminate solid tumors. Lyell is applying its proprietary ex vivo genetic and epigenetic reprogramming technology platforms, Gen-R and Epi-R, to address these barriers in order to develop new medicines with improved, durable, and potentially curative clinical outcomes. Lyell is based in South San Francisco, California and Seattle and Bothell, Washington. To learn more, please visit www.Lyell.com.

Forward-looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements expressed or implied in this press release include, but are not limited to, statements regarding: Lyells vision ofdelivering better therapeutic options for patients with solid tumors;Dr. Lees belief that Lyell is advancing one of the most promising pipelines in the industry;the potential for Lyells reprogramming technologies to overcome T-cell exhaustion and promote durable stemness; the therapeutic potential of Lyells product candidates; the anticipated benefits of a growing research team; and other statements that are not historical fact. These statements are based on Lyells current plans, objectives, estimates, expectations and intentions, are not guarantees of future performance and inherently involve significant risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, but are not limited to, risks and uncertainties related to: the effects of the evolving COVID-19 pandemic; Lyells ability to submit planned INDs on the anticipated timing or at all; initiation of planned clinical trials and enrollment of patients in its future clinical trials; Lyells ability to manufacture and supply its product candidates for its future clinical trials; the preclinical profiles of Lyells product candidates not translating in clinical trials; the potential for results from clinical trials to differ from preclinical, early clinical, preliminary or expected results; significant adverse events, toxicities or other undesirable side effects associated with Lyells product candidates; the potential for our product candidates to fail to demonstrate sufficient efficacy; the significant uncertainty associated with Lyells product candidates ever receiving any regulatory approvals; Lyells ability to obtain, maintain, or protect intellectual property rights related to its product candidates; implementation of Lyells strategic plans for its business and product candidates; the sufficiency of Lyells capital resources and need for additional capital to achieve its goals; and other risks, including those described under the heading Risk Factors in Lyells Quarterly Report on Form 10-Q for the quarter ended September 30, 2021 and Lyells future reports to be filed with the SEC. Forward-looking statements contained in this press release are made as of this date, and Lyell undertakes no duty to update such information except as required under applicable law.

Contact:Ellen RoseVice President, Communications and Investor Relationserose@lyell.com