Benzinga | Jan 27, 2022 06:53AM EST

Cue Pharma Posts Two Responses From CUE-101 Combo In Head & Neck Cancer

Early data from a trial evaluating Cue Biopharma Inc's (NASDAQ:CUE) CUE-101 combined with Merck & Co Inc's (NYSE:MRK) Keytruda (pembrolizumab) demonstrated that two out of four patients in dose-escalation cohorts had partial responses.

* The other two patients are showing reductions in target lesions.

* CUE-101, which targets IL-2, is under development as a potential third-line treatment for HPV+ recurrent/metastatic head and neck squamous cell carcinoma.

* CUE-101 + pembrolizumab combination therapy is under examination as a front-line treatment.

* Updated data on the dose-expansion CUE-101 as a monotherapy trial showed a 50% clinical benefit rate.

* The Company plans to file an Investigational New Drug (IND) application for CUE-102, another candidate from IL-2 based CUE-100 series, in Q1 of 2022.

* In January, the Company received a $3 million milestone payment from LG Chem Life Sciences under an agreement for CUE-102.

* Price Action: CUE shares closed at $10.60 on Wednesday.