Benzinga | Jan 18, 2022 09:07AM EST

Revelation Biosciences Announces First Patient Enrolled, Dosed In Phase 1b Clinical Study Of REVTx-99 For Treatment Of Allergic Rhinitis

Revelation Biosciences Inc. (NASDAQ:REVB) (the "Company" or "Revelation"), a clinical-stage life sciences company that is focused on the development of immunologicbased therapies for the prevention and treatment of disease, today announced that the first patient has been enrolled and dosed in a Phase 1b clinical study to evaluate the potential utility of REVTx-99 for treating patients with allergic rhinitis and patients with chronic nasal congestion without polyps. The clinical study is being conducted in Australia.



"In the US, approximately 8% of adults and 7% of children have allergies that cause symptoms of allergic rhinitis, also called hay fever, and patients with allergic rhinitis have a threefold greater risk of developing asthma. The risk of developing asthma increases with more severe and persistent allergic rhinitis," said James Rolke, Chief Executive Officer of Revelation. "REVTx-99 is being developed as a therapy for the millions of people who suffer from these symptoms each year -- including those related to chronic nasal congestion, in which patients with severe cases may require invasive sinus surgery. The initiation of patient enrollment is an important step in our efforts to provide patients with safe and effective treatments for these chronic issues."

The Phase 1b, randomized, double-blind, placebo-controlled, crossover design study is expected to enroll approximately 28 participants. The primary endpoint is to evaluate the effects of REVTx-99 versus placebo on safety and tolerability. Key secondary endpoints include allergy symptoms (Total Nasal Symptom Score) and peak nasal inspiratory flow elicited by nasal allergen challenge. The study will have two cohorts: one cohort will receive study drug before the nasal allergen challenge (the prophylactic cohort) and the second cohort will receive study drug after the nasal allergen challenge (the treatment cohort).

The company expects the topline data in the first half of 2022.

For more information on Revelation, please visit www.RevBiosciences.com.