Benzinga | Jan 12, 2022 08:33AM EST

Lixte Biotechnology Announces Filing Of First Patent Application Resulting From Collaboration With the Netherlands Cancer Institute And The Oncode Institute To Identify The Most Promising Drug Combinations For Lead Clinical Compound, LB-100

Lixte Biotechnology Holdings, Inc. (NASDAQ:LIXT) reported that its the recent collaboration with the Netherlands Cancer Institute (NKI), Amsterdam, one of the world's leading comprehensive cancer centers, and Stichting Oncode Institute (Oncode Institute), Utrecht, a major independent cancer research center, has led to an initial joint patent application covering LB-100 combination therapy with one of several other investigational compounds. Lixte, NKI and Oncode Institute believe that the combination therapy would provide unexpectedly strong synergistic anti-cancer effects in cancer patients.

Lixte previously announced its entry into a collaboration with the NKI and Oncode Institute to identify the most promising drugs to be used in combination with Lixte's LB-100 or with one of Lixte's LB-100 analogues to treat a range of cancers, as well as to identify the specific molecular mechanisms underlying the identified combinations.

John S. Kovach, MD, the founder and CEO of Lixte, commented "The new findings support the hypothesis advanced by Professor Bernards at the NKI (Dias and Bernards, Mol Onc, 2021) that rather than the usual therapeutic approach to cancer -- inhibiting overactive pathways that drive cancer growth -- further stimulation of those pathways can overwhelm the cancer cells, rendering them exceptionally vulnerable to particular stress-targeted drugs, while sparing the normal cells. This 'paradoxical intervention' is truly groundbreaking and may be applicable to a broad range of cancers."