Benzinga | Dec 20, 2021 07:35AM EST

InMed Pharmaceuticals Announces Publication Of Peer-Reviewed Article On The Use Of CBN As A Potential Treatment For Glaucoma

InMed Pharmaceuticals Inc. ("InMed" or the "Company") (NASDAQ:INM), a leader in the development, manufacturing and commercialization of rare cannabinoids, today announced that a peer-reviewed scientific article entitled "Cannabinol Modulates Neuroprotection and Intraocular Pressure: A Potential Multi-Target Therapeutic Intervention for Glaucoma", has been published in Biochimica et Biophysical Acta (BBA - Molecular Basis of Disease), a leading international journal focused on biochemistry and molecular genetics of disease processes and models of human disease in the area of aging, cancer, metabolic-, neurological-, and immunological-based diseases.



The peer-reviewed article highlights research evaluating the use of cannabinol, or CBN, as a potential treatment option for glaucoma. Several studies were conducted to evaluate the survival of retinal ganglion cells, modulation of intraocular pressure and its effects on extracellular matrix proteins using in vitro and in vivo glaucoma models.

These studies resulted in two key findings: first, CBN may promote neuroprotection of cells in the retina that are responsible for vision; and second, CBN may normalize intraocular pressure by attenuating changes in the extracellular matrix proteins. The article also reports on the comparison of CBN with other cannabinoids, including cannabidiol (CBD) and tetrahydrocannabinol (THC), with results indicating that CBN has a stronger effect and broader neuroprotective therapeutic range. These observations elucidate the therapeutic potential for CBN in the treatment of glaucoma.

"Having this research peer-reviewed and published in such a reputable journal is a significant milestone for InMed's glaucoma development program. This provides important external validation for the scientific community as the program advances towards human studies", said InMed's scientific advisor, Dr. Mauro Maccarrone, Professor and Chair of Biochemistry at the Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy. "We believe InMed's INM-088 program has significant implications for neuroprotection within the glaucoma space and may lead to a potential new treatment for millions of people suffering from this condition worldwide."

Corresponding author Professor Ujendra Kumar, Faculty of Pharmaceuticals, The University of British Columbia, added; "The observations in this study indicate the therapeutic potential for the use of CBN in the treatment of glaucoma. Not only does the data suggest a reduction in ocular pressure but also proactive neuroprotection in the retina, both of which are integral to the treatment of glaucoma. This publication is further evidence to suggest rare cannabinoids have therapeutic potential to treat various diseases."