Benzinga | Dec 8, 2021 08:21AM EST

Palisade Bio Reports Granted New US Patent Covering Protease Inhibitor LB1148 For Treating Adhesions, Postoperative Ileus

Issuance of Additional U.S. Patent No11,202,768 Further Bolsters Palisade Bio's Patent Portfolio

The Company Continues to Advance LB1148 for Key Indications After LB1148 Topline Efficacy Results from Phase 2 Trial Demonstrated Accelerated Return of Bowel Function Following Gastrointestinal Surgery

CARLSBAD, Calif., Dec. 08, 2021 (GLOBE NEWSWIRE) -- Palisade Bio, Inc. (NASDAQ:PALI), a clinical stage biopharmaceutical company advancing therapies for acute and chronic gastrointestinal (GI) complications, today announces that the United States Patent and Trademark Office (USPTO) has granted a new U.S. patent for the company's lead investigational drug product, LB1148, for use in treating adhesions and postoperative ileus. The U.S. Patent No. 11,202,768 will issue on December 21, 2021.

The issuance of this grant is the first of a recent patent family directed to the use of LB1148 in treating ileus (disruption of the normal propulsive ability of the intestine) and adhesions, and it confers broad coverage of the components in LB1148 for such treatments until 2037.

"This new patent adds to Palisade Bio's growing intellectual property (IP) estate for LB1148 and continues to support our clinical studies of LB1148 in surgery patients. It specifically covers the use of LB1148 for the lead indications for which we plan to seek approval," said Tom Hallam, Ph.D., CEO of Palisade Bio. "This additional IP protection for LB1148 is a major milestone as we advance our clinical pipeline and provide further data from our study of LB1148 for GI surgery patients. With this grant from the USPTO, we now have patents from three distinct families protecting LB1148 and its uses in the U.S., and we continue to pursue and obtain multi-family patent protection of LB1148 outside the United States to strengthen global IP protections."

Palisade Bio is investigating LB1148 for use in reducing adhesions and postoperative ileus, which received Fast Track Designation from the FDA earlier this year. In Phase 2 clinical trials, LB1148 demonstrated statistically significant improvements in accelerating the time to return of postoperative bowel function in gastrointestinal and cardiovascular surgery, and early observations also point to a reduction in adhesions following GI surgery.