Benzinga | Nov 17, 2021 09:08AM EST

Arrowhead Announces JNJ-75220795 In Development For NASH

Arrowhead Pharmaceuticals Inc. (NASDAQ:ARWR) today announced that its collaborator, Janssen Pharmaceuticals, Inc., (Janssen) one of the Janssen Pharmaceutical Companies of Johnson & Johnson, has disclosed its collaboration with Arrowhead on investigational compound JNJ-75220795, which is in a Phase 1 clinical study.

JNJ-75220795 is an investigational siRNA therapeutic developed using Arrowhead's proprietary TRIMTM platform and designed to reduce expression in the liver of patatin like phospholipase domain containing 3 (PNPLA3) as a potential treatment for patients with non-alcoholic steatohepatitis (NASH). PNPLA3 has strong genetic and preclinical validation as a driver of fat accumulation and damage in the livers of patients who carry the common I148M mutation.

Arrowhead entered into a research collaboration and option agreement with Janssen in October 2018, which resulted in collaboration on JNJ-75220795.