Benzinga | Nov 11, 2021 09:08AM EST

GlycoMimetics Highlights GMI-1359 Data Selected For Presentation At American Society Of Hematology Meeting Dec. 11 And 13

* Two poster presentations detailing preclinical studies conducted at MD Anderson Cancer Center will highlight data demonstrating the potential of the Company's dual antagonist of CXCR4 and E-selectin

ROCKVILLE, Md.--(BUSINESS WIRE)-- GlycoMimetics, Inc. (NASDAQ:GLYC) today announced that two abstracts relating to GMI-1359, the Company's dual antagonist of CXCR4 and E-selectin, have been accepted for poster presentations at the 63rd American Society of Hematology (ASH) Annual Meeting and Exposition, to be held December 11-14, 2021.

"The data to be presented at ASH provide further support for targeting both CXCR4 and E-selectin as a novel treatment strategy for patients with AML, particularly patients with FLT-3 ITD mutations. Both posters detail preclinical studies conducted at the MD Anderson Cancer Center at the University of Texas in Houston, under the direction of Dr. Michael Andreeff. The first poster (#1171) describes the unexpected activities of FLT-3 inhibitors such as quizartinib and sorafenib to upregulate the expression of E-selectin ligands (sialyl Lex) and CXCR4 thereby increasing adhesion to protective niches in the bone marrow microenvironment and inducing chemoresistance. The addition of GMI-1359 to quizartinib in a PDX mouse model from a relapsed patient broke this induced chemoresistance, leading to a dramatic reduction in leukemic burden and a near-doubling of survival time. The second (#3348) demonstrates that GMI-1359 reduced adhesion and stimulated mobility of leukemic stem cells within the bone marrow microenvironment. In AML mouse models, GMI-1359 increased the efficacy and extended survival time in engrafted mice treated with venetoclax/HMA while protecting the hematopoietic stem cells and the bone marrow components from this treatment," said John Magnani, GlycoMimetics' Chief Scientific Officer.

Details on GlycoMimetics posters at the ASH Meeting are as follows:

1. Poster# 1171

Title: FLT3 Inhibitors Upregulate CXCR4 and E-selectin Ligands and CD44 Via ERK Suppression in AML Cells, and Blockade of CXCR4 and E-selectin Signaling with GMI-1359 Overcomes AML Resistance to Quizartinib In Vitro and In Vivo.Authors: Y. Jia, M. Basyal, L. Ostermann, W.E. Fogler, J.L. Magnani, T. Seki, W. Zhang, M. Andreeff

Session Name: 604. Molecular Pharmacology and Drug Resistance: Myeloid Neoplasms: Poster I

Date/Time: Saturday, December 11, 5:30-7:30 p.m. ET, Georgia World Congress Center, Hall B5

2. Poster# 3348

Title: Co-targeting E-selectin/CXCR4 with GMI-1359 Facilitates AML Stem Cell Mobilization and Protects BM Niches from Anti-leukemia Therapy.Authors: K.-H. Chang, T. Zal, M. Basyal, L. Ostermann, M. Muftuoglu, P. Y. Mak, Y. Jia, W. Tao, A. Zal, W.E. Fogler, J.L. Magnani, W. Zhang, B.Z. Carter, M. Andreeff

Session Name: 604. Molecular Pharmacology and Drug Resistance: Myeloid Neoplasms: Poster III

Date /Time: Monday, December 13, 6:00-8:00 p.m. ET, Georgia World Congress Center, Hall B5

The accepted abstracts are available online through the ASH meeting website.