Benzinga | Nov 9, 2021 11:35AM EST

Alterity Therapeutics Announces Presentation Of ATH434 At American Autonomic Society Virtual Meeting 2021

Alterity Therapeutics ((ASX: ATH, NASDAQ:ATHE) ("Alterity" or "the Company"), a biotechnology company dedicated to developing disease modifying treatments for neurodegenerative conditions, today announced a poster presentation and accompanying video were delivered at the American Autonomic Society 32nd Annual Internation Symposium on the Autonomic Nervous System.

The poster, entitled, Cardiovascular safety and pharmacokinetics of ATH434, a novel small molecule inhibitor of ?-synuclein aggregation, in adults and older adults, described results from the Company's Phase 1 clinical trial conducted in healthy volunteers. In the Phase 1 trial, ATH434 was well tolerated in adult and ? 65 year-old volunteers and demonstrated no cardiac adverse event signal and no clinically significant changes in blood pressure or heart rate at any dose. ATH434 also demonstrated dose dependent pharmacokinetics (PK) after single and multiple oral doses and a half-life that supports twice-daily dosing.

"The promising safety profile and oral bioavailability of ATH434 supports our Phase 2 clinical trial design in patients with multiple system atrophy (MSA)," said David Stamler, M.D., Chief Executive Officer, Alterity. "We believe that the option for administration in pill form may provide a convenient treatment option for individuals with MSA. We look forward to initiating our Phase 2 clinical trial in MSA in the first quarter of next year."

In addition, Daniel Claassen, MD, gave a plenary lecture on the imaging methods for MSA which included findings from Alterity's Biomarkers of progression in Multiple System Atrophy (bioMUSE) natural history study, available here. Dr. Claasen is Associate Professor of Neurology, Vanderbilt University Medical Center and Principal Investigator of bioMUSE.

Alterity's poster presentation and accompanying video will be available on the Company's website.