Benzinga | Nov 4, 2021 09:33AM EDT

Precigen Achieves Significant Clinical Progress For UltraCAR-T And AdenoVerse Therapies

- 50% (3 out of 6) objective response rate (ORR) in relapsed or refractory (r/r) acute myeloid leukemia (AML) patients treated with PRGN-3006 at the two lowest dose levels (a single administration of 4 to 28 million UltraCAR-T cells) in the lymphodepletion cohort of the ongoing Phase 1 trial -

- 40% ORR (2 out of 5) and 60% disease control rate (DCR) (3 out of 5) in recurrent or metastatic human papilloma virus (HPV)-associated cancer patients treated in the PRGN-2009 combination arm of the ongoing Phase 1 trial -

- Preliminary PRGN-2012 Phase 1 data show encouraging clinical activity, including ongoing reduction/elimination of the need for surgical intervention at the most recent follow-up, up to 12 weeks after PRGN-2012 treatment -

- PRGN-3005 and PRGN-3006 UltraCAR-T demonstrate favorable safety profiles with no dose-limiting toxicities or neurotoxicity, dose-dependent in vivo expansion and durable persistence -

- PRGN-2009 and PRGN-2012 AdenoVerse immunotherapies demonstrate favorable safety profiles with no dose-limiting toxicities, strong antigen-specific immune response and lack of significant neutralizing antibody response upon repeat administrations -

- PRGN-3006 clinical abstract (Abstract# 825) selected for oral presentation at the 63rd American Society of Hematology (ASH) Annual Meeting and Exposition -

- Precigen to host 2021 R&D Day virtual event today at 11:00 AM ET -