GlobeNewswire Inc | Jul 23, 2020 07:00AM EDT

July 23, 2020

LAUSANNE, Switzerland, July 23, 2020 (GLOBE NEWSWIRE) -- AC Immune SA (NASDAQ: ACIU), a Swiss-based, clinical-stage biopharmaceutical company, with a broad pipeline focused on neurodegenerative diseases, today announced two oral presentations will be delivered at this years Alzheimers Association International Conference (AAIC) which takes place virtually July 27 31, 2020.

Key data will be presented on the Companys alpha-synuclein-positron emission tomography (PET) tracer program along with a second oral presentation by the Coordinating Principal Investigator of the Phase 1b trial of the anti-Abeta vaccine ACI-24 in Down syndrome, Dr. Michael Rafii who is a world authority on Down syndrome-related Alzheimers disease. Both research programs are the most advanced in their field.

Prof. Andrea Pfeifer, CEO of AC Immune SA, commented: This years AAIC presentations reflect the ongoing strength and depth of our industry leading pipeline. There is increasing recognition that the complexity of neurodegenerative disease pathology will only be solved utilizing the type of diversified approach pioneered by AC Immune. This is why our pipeline spans both cutting-edge therapeutic and diagnostic programs on well-established targets like Abeta, as well as novel targets and mechanisms.

Compelling results1 just published from the first large, multi-national study to track clinical and biomarker changes of Down syndrome-related Alzheimers disease further validate the approach of testing our anti-Abeta vaccine ACI-24 in individuals with Down syndrome as a key population for trials to target Alzheimers disease in genetic, more homogeneous populations.

The presentations further highlight the enduring power of our clinically validated proprietary Morphomer and SupraAntigen platforms to accelerate the discovery, design and development of novel medicines and diagnostics to target misfolded proteins.

Scientific updates at the AAIC 2020 Virtual Event, July 2731, 2020

Alpha-synuclein PET tracerTitle: Developing a novel alpha-synuclein-positron emission tomography (PET) tracer for the diagnosis of a-synucleinopathiesDate: Tuesday, July 28, 2020 | 12:00am ? 11:59pmSession: Neuroimaging: Other Neurodegenerative DisordersPresenter: Oral presentation by Dr. Francesca Capotosti

ACI-24 anti-Abeta vaccineTitle: ACI-24 Vaccine in Adults with Down Syndrome (3 Star Trial)Date: Wednesday, July 29, 2020 | 12:00 am ? 11:59pmSession: Human: Putative Therapeutic Results for Alzheimer's and Related Dementias Oral presentation by Dr. Michael Rafii, Alzheimer?s TherapeuticPresenter: Research Institute, Keck School of Medicine of University of Southern California

References

-- Fortea et al, Lancet 2020; 395: 198897

About AC Immune SA AC Immune SA is a Nasdaq-listed clinical-stage biopharmaceutical company, which aims to become a global leader in precision medicine for neurodegenerative diseases. The Company utilizes two proprietary platforms, SupraAntigenTMand MorphomerTM, to design, discover and develop small molecule and biological therapeutics as well as diagnostic products intended to diagnose, prevent and modify neurodegenerative diseases caused by misfolding proteins. The Company's pipeline features nine therapeutic and three diagnostic product candidates, with six currently in clinical trials. It has collaborations with major pharmaceutical companies including Genentech, a member of the Roche group, Eli Lilly and Company and Janssen Pharmaceuticals.

For further information, please contact:

Head of Investor Relations US MediaJoshua Drumm, Ph.D. Katie GallagherAC Immune LaVoieHealthSciencePhone: +1 917 809 0814 Phone: +1 617 792 3937Email: joshua.drumm@acimmune.com Email: kgallagher@lavoiehealthscience.com Global Head of Communications European Investors & MediaJudith Moore Chris MaggosAC Immune LifeSci AdvisorsPhone: +41 79 826 63 82 Phone: +41 79 367 6254Email: judith.moore@acimmune.com Email: chris@lifesciadvisors.com

Forward looking statementsThis press release contains statements that constitute forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical fact and may include statements that address future operating, financial or business performance or AC Immunes strategies or expectations. In some cases, you can identify these statements by forward-looking words such as may, might, will, should, expects, plans, anticipates, believes, estimates, predicts, projects, potential, outlook or continue, and other comparable terminology. Forward-looking statements are based on managements current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include those described under the captions Item 3. Key Information Risk Factors and Item 5. Operating and Financial Review and Prospects in AC Immunes Annual Report on Form 20-F and other filings with the Securities and Exchange Commission. These include: the impact of Covid-19 on our business, suppliers, patients and employees and any other impact of Covid-19. Forward-looking statements speak only as of the date they are made, and AC Immune does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law. All forward-looking statements are qualified in their entirety by this cautionary statement.