Benzinga | Oct 27, 2021 06:49AM EDT

Aptinyx Announced it Completed Enrollment in Phase 2b Study of NYX-2925 in Painful Diabetic Peripheral Neuropathy

Aptinyx Inc. (NASDAQ:APTX), a clinical-stage biopharmaceutical company developing transformative therapies for the treatment of brain and nervous system disorders, today announced the completion of enrollment in the company's ongoing Phase 2b study of NYX-2925 for the treatment of painful diabetic peripheral neuropathy (DPN). Patients recently enrolled in the study are completing the 12-week treatment period and 30-day safety follow-up period. The company expects to report results from the study in early to mid 2Q 2022.

"Today's milestone represents an exciting achievement as we advance the development of NYX-2925 for the treatment of painful DPN," said Norbert Riedel, Ph.D., chief executive officer of Aptinyx. "Despite a difficult environment for the conduct of clinical studies in the midst of a pandemic, our team's stellar efforts and execution have completed enrollment on schedule. We believe this reflects the high interest from patients and physicians in a new treatment option with the potential to alleviate pain and avoid the harmful side effects and risk of addiction in current therapies. We look forward to completing the study and reporting results next year, which, if positive, would support the late-stage clinical development of NYX-2925 in painful DPN. This readout will be the first of the multiple Phase 2 data catalysts we expect across our development pipeline over the next 24 months."

The Phase 2b study is evaluating the efficacy and safety of NYX-2925 in patients with advanced painful DPN. The primary endpoint in the study is the change from baseline in weekly average daily pain score over a 12-week period as reported on the 10-point numeric rating scale (NRS).