Benzinga | Oct 25, 2021 08:05AM EDT

DICE Therapeutics Reports Initiation Of Phase 1 Trial Of S011806 For Treatment Of Psoriasis

DICE Therapeutics, Inc. (NASDAQ:DICE), a biopharmaceutical company leveraging its proprietary technology platform to build a pipeline of novel oral therapeutic candidates to treat chronic diseases in immunology and other therapeutic areas, today announced that the first healthy volunteer has been dosed in the Company's Phase 1 clinical trial of S011806. S011806 is an orally-available, small molecule antagonist of the pro-inflammatory cytokine, interleukin-17 (IL-17), which is a validated drug target for the treatment of a variety of immunological diseases. The Phase 1 trial of S011806 is designed to generate safety and pharmacokinetic data, as well as provide early clinical proof-of-concept in psoriasis patients.

"S011806 is designed to be a highly selective and potent orally administered inhibitor of the IL-17 cytokine, a well-validated target in psoriasis, psoriatic arthritis, ankylosing spondylitis and non-radiographic axial spondylarthritis," said Kevin Judice, Ph.D., founder and CEO of DICE Therapeutics. "The initiation of this clinical trial for S011806, the first of several programs in our IL-17 franchise, marks a major milestone in our mission to bring an effective and convenient oral therapy to patients suffering from IL-17 mediated diseases like psoriasis."

The Phase 1 clinical trial is a first-in-human, randomized, double-blind, placebo-controlled study that will evaluate S011806 in healthy volunteers and psoriasis patients in the UK. The trial will evaluate single and multiple ascending doses in healthy volunteers to understand the safety and pharmacokinetics of S011806. In addition, the Phase 1 clinical trial will evaluate the safety, pharmacokinetics, pharmacodynamics and efficacy of S011806 across two dose regimens in psoriasis patients, which could provide early clinical proof-of-concept and dose selection guidance for use in future studies.