Benzinga | Oct 21, 2021 12:11PM EDT

MediciNova Announces Abstract Regarding The Mechanism By Which MN-001 Alters Triglyceride Metabolism Accepted For Presentation At The 19th International Symposium On Atherosclerosis

MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ Global Market (NASDAQ:MNOV) and the JASDAQ Market of the Tokyo Stock Exchange (Code Number: 4875), today announced an abstract entitled "MN-001 (tipelukast) reduces triglycerides levels in hepatocytes by down-regulating fatty acid translocase/CD36 expression" has been selected for presentation at the 19th International Symposium on Atherosclerosis (ISA2021) to be held October 24 - 27, 2021 in a hybrid format both online and onsite at the Kyoto International Conference Center in Kyoto, Japan.

This study showed that MN-001 (tipelukast) inhibited the uptake of arachidonic acid into hepatocytes and suppressed the synthesis and accumulation of triglycerides (TG) in hepatocytes. These phenomena, which are consistent with earlier findings, suggested that MN-001 (tipelukast) reduced the synthesis and accumulation of TG in hepatocytes by suppressing the expression of CD36.

MediciNova's research collaborator, Dr. Masatsune Ogura, Associate Professor at the Department of General Medical Science, Chiba University Graduate School of Medicine, will present the results of the study. Dr. Ogura's e-presentation with narration will be accessible on the ISA2021 website from October 25 to November 30, 2021.

Kazuko Matsuda, M.D. Ph.D, MPH., Chief Medical Officer, MediciNova, Inc., commented, "It has been observed that MN-001 treatment reduces serum TG levels in multiple previous clinical trials. Particularly, in a Phase 2 clinical trial with hypertriglyceridemia subjects with NASH or NAFLD, MN-001 demonstrated a clinically meaningful and statistically significant reduction in mean serum TG with no safety or tolerability issues. We are very pleased that Dr. Ogura will present new findings regarding the mechanism by which MN-001 alters intracellular triglyceride metabolism."