Benzinga | Oct 4, 2021 04:01PM EDT

Amgen Announces New Data Highlighting Global Trends In Hip Fracture Incidence And Treatment

Amgen (NASDAQ:AMGN) today announced results from real-world data in Asia, Europe, Oceania, and North and South America on the temporal trends in hip fracture incidence, and in post-fracture pharmacological treatment intervention. The study, presented as a late-breaking abstract at the American Society for Bone and Mineral Research 2021 Annual Meeting (ASBMR), is titled "Hip Fractures: Initial Report of Trends in Incidence, Treatment, and Mortality In Multiple Countries Using a Common Analytical Platform." The results of the study reveal that hip fracture remains a significant public health issue across the globe, and that the effects of aging populations and suboptimal pharmacological treatment may contribute to an increasing burden of osteoporosis.i

"Hip fractures represent a major public health crisis, but previously available reports on incidence are based on decades old data for some regions," said Darryl Sleep, M.D., senior vice president of Global Medical and chief medical officer at Amgen. "We are excited to present the latest global data on hip fractures, which uses a unified methodology that makes it possible to provide updated incidence, as well as valuable insights on the risk factors and next steps in the treatment of osteoporosis."

This study, led by the University of Hong Kong, was funded by Amgen and includes Amgen authors. This initial report, inclusive of years 2005 and 2018, is based on thirteen data sources from Australia, Canada, Germany, Hong Kong, Italy, the Netherlands, New Zealand, South Korea, Spain, Taiwan, United Kingdom, and two systems (Medicare and Optum's de--identified Clinformatics(r) Data Mart Database) from the United States.i The change in age-standardized hip fracture incidence varied from -2.1% to +2.3% per year across all data sources (HK, -2.1%; UK, -1.3%; TW, -1.8%; IT, -1.4%; Spain, -1.1%; USM, -1.1%; Canada, -0.9%; NZ, -0.8%; USO, -0.2%; AU, +0.2%; GE, +0.8%; SK, +0.8%; NL, +2.3%); those data sources with full population coverage show the absolute number of hip fractures per year has increased. Post-fracture care with pharmacological treatment within 12 months after fracture ranged from 11.5% to 50.3% across the globe, with recent annual trends notably decreasing in some health care systems (e.g. United States Medicare).i

"This study examined patients over 50 years old who were hospitalized due to a hip fracture. Although hip fracture incidence has been stabilized or reduced in many countries in recent years, this reduction is insufficient to offset the increase of hip fractures as the global population ages," said lead investigator, Chor-Wing Sing, PhD, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong. "The current results also show low post-hip fracture treatment rates, which suggest that prevention efforts following hip fractures can be improved. Such efforts are critical, given that following a hip fracture, postmenopausal women are 2.5 times more likely to break another bone."