GlobeNewswire Inc | Sep 28, 2021 07:00AM EDT

September 28, 2021

Silence Therapeutics to Participate in Fireside Chat at the Chardan Virtual Genetic Medicines Conference

28 September 2021

LONDON, Silence Therapeutics plc, AIM: SLN and Nasdaq: SLN (Silence or the Company), a leader in the discovery, development and delivery of novel short interfering ribonucleic acid (siRNA) therapeutics for the treatment of diseases with significant unmet medical need, today announced that the Company will participate in a fireside chat at the Chardan Virtual Genetic Medicines Conference on Tuesday, October 5th at 8:30 a.m. EDT / 1:30 p.m. BST.

A live webcast of the fireside chat can be accessed via the Investors section of the Silence website at www.silence-therapeutics.com. An archived replay of the webcast will be available on the Companys website following the conference.

Enquiries:

Silence Therapeutics plc

Gem Hopkins, Head of IR and CorporateCommunications Tel: +1 (646) 637-3208ir@silence-therapeutics.com

Investec Bank plc (Nominated Adviser andBroker) Tel: +44 (0) 20 7597Daniel Adams/Gary Clarence 5970

European PR

Consilium Strategic Communications

Mary-Jane Elliott/ Angela Gray / Chris Welsh Tel: +44 (0) 20 3709 5700

silencetherapeutics@consilium-comms.com

About Silence TherapeuticsSilence Therapeutics is developing a new generation of medicines by harnessing the body's natural mechanism of RNA interference, or RNAi, to inhibit the expression of specific target genes thought to play a role in the pathology of diseases with significant unmet need. Silence's proprietary mRNAi GOLD platform can be used to create siRNAs (short interfering RNAs) that precisely target and silence disease-associated genes in the liver, which represents a substantial opportunity. Silence's wholly owned product candidates include SLN360 designed to address the high and prevalent unmet medical need in reducing cardiovascular risk in people born with high levels of lipoprotein(a) and SLN124 designed to address iron-loading anemia conditions. Silence also maintains ongoing research and development collaborations with AstraZeneca, Mallinckrodt Pharmaceuticals, and Takeda, among others. For more information, please visit https://www.silence-therapeutics.com/.