GlobeNewswire Inc | Sep 28, 2021 04:19AM EDT

September 28, 2021

LONDON and NEW YORK, Sept. 28, 2021 (GLOBE NEWSWIRE) -- Tiziana Life Sciences plc (Nasdaq: TLSA / LSE: TILS) ("Tiziana" or the "Company"), a biotechnology company focused on innovative therapeutics for oncology, inflammation and infectious diseases, today announces that it has been notified that Panetta Partners Limited, an entity in which Gabriele Cerrone, the Executive Chairman has a beneficial interest, purchased 100,000 ordinary shares of 3p each in the market at a price of 52p per share.

The acquisition takes Mr Cerrone's interests from 34.078% to 34.129% (within the 1% incremental threshold under Note 11 to Rule 9 of the UK Takeover Code).

1. Details of PDMR / person closely associateda) Name Gabriele Cerrone2. Reason for the notificationa) Position / status Chairmanb) Initial notification /amendment Initial notification3. Details of the issuera) Name Tiziana Life Sciences plcb) LEI 213800CED47HI8PIOB36 Details of the transaction(s): section to be repeated for (i) each type of4. instrument; (ii) each type of transaction; (iii) each date; and (iv) each place where transactions have been conducteda) Description of the financial Ordinary Shares of 3p each instrumentb) Identification code of the Financial ISIN for Tiziana Life Sciences plc: Instrument GB00BKWNZY55c) Nature of the transaction Market Purchase 52pd) Price(s) and volume(s) 100,000f) Date of the transaction 27 September 2021g) Place of the transaction XLON

About Tiziana Life Sciences

Tiziana Life Sciences plc is a dual listed (NASDAQ:TLSA, UK LSE: TILS) biotechnology company that focuses on the discovery and development of novel molecules to treat human diseases in oncology, inflammation and infectious diseases. In addition to Milciclib, the Company will be shortly initiating Phase 2 studies with orally administered Foralumab for Crohn's Disease and nasally administered Foralumab for progressive multiple sclerosis. Foralumab is the only fully human anti-CD3 monoclonal antibody ("mAb") in clinical development in the world. This Phase 2 compound has potential application in a wide range of autoimmune and inflammatory diseases, such as Crohn's Disease, multiple sclerosis, type-1 diabetes ("T1D"), inflammatory bowel disease ("IBD"), psoriasis and rheumatoid arthritis, where modulation of a T-cell response is desirable. The Company is accelerating development of anti-Interleukin 6 receptor ("IL6R") mAb, a fully human monoclonal antibody for treatment of IL6-induced inflammation, especially for treatment of COVID-19 patients.

For further enquiries:

Tiziana Life Sciences plc +44 (0)20 7495 2379Gabriele Cerrone, Chairman, and founder

United States:Investors:Dave Gentry, CEORedChip Companies Inc.407-491-4498dave@redchip.com