Benzinga | Sep 24, 2021 06:57AM EDT

GlycoMimetics' Lead Candidate Data Published In An Online Journal

* GlycoMimetics Inc (NASDAQ:GLYC) has announced that efficacy and safety data from a Phase 1/2 study of uproleselan were published online in the journal BLOOD.

* In the manuscript, scientists highlighted an analysis of minimal residual disease (MRD).

* The paper's lead author noted that "the combination of uproleselan with a standard salvage regimen of mitoxantrone, etoposide and cytarabine (MEC) demonstrated a substantial improvement in response rate and survival compared to chemotherapy alone."

* The paper also confirms that uproleselan can be safely combined with an intensive salvage chemotherapy regimen without adding toxicity in relapsed/refractory and newly diagnosed older AML patients.

* Of the 16 evaluable patients, 11 patients (69%) were MRD negative at the end of induction.

* Following treatment with MEC plus uproleselan, 31% of patients (17/54) underwent an allogeneic hematopoietic stem cell transplant.

* Of the 22 patients achieving CR/CRi, 11 (50%) underwent transplants.

* Median overall survival in relapsed/refractory and newly diagnosed AML patients was 8.8 and 12.6 months, respectively.

* The addition of uproleselan was associated with low rates of oral mucositis.

* Price Action: GLYC stock is down 0.87% at $2.27 during the premarket session on the last check Friday.