Benzinga | Sep 3, 2021 05:45AM EDT

Novartis Presents New Findings at ERS Congress Reinforcing Efficacy of Enerzair Breezhaler, Highlighting Its Digital Companion, Showcasing Commitment to Low Carbon Footprint Asthma Solutions

Novartis (NYSE:NVS) today announced 12 Enerzair(r) Breezhaler(r) (indacaterol acetate, glycopyrronium bromide and mometasone furoate [IND/GLY/MF]) and Atectura(r) Breezhaler(r) [indacaterol acetate and mometasone furoate [IND/MF] abstracts to be presented at the upcoming European Respiratory Society (ERS) International Congress 2021, taking place virtually from September 5 - September 8, 2021. The data further establish the efficacy of Enerzair Breezhaler and will be unveiled alongside an interim analysis highlighting patient engagement and adherence levels with Enerzair Breezhaler's optional digital companion (sensor and app)3-6. In keeping with the Novartis commitment to reduce the environmental impact of its asthma combinations, Novartis will also share new data exploring the carbon footprint of Enerzair Breezhaler use7.

'Our presence at ERS this year reiterates our commitment to patients through the further development of first-in-class therapies like Enerzair Breezhaler, as well as by exploring the potential of digital health companions and the carbon footprint of our solutions,' said Dominic Brittain,Respiratory Global Program Head, Novartis Pharmaceuticals. 'As a global leader in respiratory and allergy, we remain committed to reimagining medicine for patients living with chronic respiratory diseases like asthma.'

Highlights of Enerzair Breezhaler data at the ERS Congress 2021 include:

New post hoc analysis results from the Phase III IRIDIUM study that suggests that using Enerzair Breezhaler as a step-up therapy from medium-dose LABA/ICS provides benefit beyond increasing ICS dose alone4.

Efficacy of mometasone/indacaterol/glycopyrronium (MF/IND/GLY) on lung function and exacerbations in patients with inadequately controlled asthma with medium-dose ICS/LABA therapy (on GINA step 4) prior to study entry: Results from IRIDIUM study. H.A. Kerstjens et al.Details: PosterNew post hoc analysis from the Phase III PLATINUM program in which Atectura Breezhaler and Enerzair Breezhaler showed clinical benefit compared to two widely used therapies3.

Mometasone/indacaterol (MF/IND) and mometasone/indacaterol/glycopyrronium (MF/IND/GLY) versus fluticasone/salmeterol (FLU/SAL) and FLU/SAL+tiotropium (TIO) in patients with inadequately controlled asthma: data from the PLATINUM program.R. Van Zyl-Smit et al.Details: PosterNew post hoc analysis from the Phase III IRIDIUM study showed how each of the three components in Enerzair Breezhaler contribute to the substantial (36-42%) reduction in exacerbations seen versus twice daily high-dose SAL/FLU5.

Evaluating contributions of mometasone (MF), indacaterol (IND) and glycopyrronium (GLY) to reduction of exacerbations in patients with inadequately controlled asthma: Results from the IRIDIUM study.K. R. Chapman et al.Details: Oral Presentation, 6 September, 9:30-11:00 CESTAn interim analysis of patient engagement and adherence assessment in Germany indicates patients with asthma using once daily Enerzair Breezhaler and digital companion (sensor and app) had a 72% engagement rate at baseline and maintained an 82% medication adherence rate over three months of treatment6.

Assessment of patient engagement and adherence with once-daily indacaterol/glycopyrronium/mometasone (IND/GLY/MF) Breezhaler digital companion in asthma: interim analysis from Germany.H. Woehrle et al.Details: Oral Presentation, 7 September, 14:45-16:15 CESTData suggesting that the treatment of severe asthma exacerbations may have a negative environmental impact due to ambulance trips, emergency room visits and hospitalizations: the carbon footprint of a single severe asthma exacerbation could be equivalent to the use of a dry powder inhaler (Breezhaler(r)) for approximately 74 years7.

Carbon footprint of severe asthma exacerbation management relative to Breezhaler dry powder inhaler.K.M. Beeh et al.Details: Oral Presentation, 5 September, 9:30-11:00 CEST*Indacaterol acetate (IND)/glycopyrronium bromide (GLY)/mometasone furoate (MF)**Indacaterol acetate (IND)/mometasone furoate (MF) Long-acting beta2-agonist (LABA)/long-acting muscarinic antagonist [LAMA]/inhaled corticosteroids (ICS)^Long-acting beta2-agonist (LABA)/inhaled corticosteroids (ICS)