Benzinga | Jul 16, 2021 08:05AM EDT

Bristol-Myers' Opdvio/Yervoy Combo Therapy Flunks In Head & Neck Cancer Trial

* Bristol Myers Squibb & Co's (NYSE:BMY) Phase 3 CheckMate -651 data evaluating Opdivo (nivolumab) plus Yervoy (ipilimumab) combo in head and neck cancer failed to primary endpoints of the trial.

* The trial assessed Opdivo plus Yervoy combination to Extreme regimen (cetuximab, cisplatin/carboplatin, and fluorouracil) as a first-line treatment in platinum-eligible patients with recurrent or metastatic squamous cell carcinoma of the head and neck.

* The combination treatment did show a clear, positive trend towards overall survival (OS) in patients whose tumors express PD-L1.

* The safety profile of Opdivo and Yervoy in this trial was consistent with previously reported studies in solid tumors.

* The company will complete a full evaluation of the data and work with investigators to share the results with the scientific community.

* Price Action: BMY shares are down 0.83% at $66.87 during the premarket session on the last check Friday.