Benzinga | Jun 14, 2021 04:11PM EDT

Pharmaceuticals Announces Preliminary Safety And Dosimetry Results From Single-Dose Portion Of Phase 1 Study Of FPI-1434 ; Says Candidate 'demonstrated a favorable safety profile with no drug-related serious adverse events or dose-limiting toxicity'

Product candidate FPI-1434, administered at three different dose levels, demonstrated a favorable safety profile with no drug-related serious adverse events or dose-limiting toxicity

Imaging shows drug uptake across multiple tumor types

Enrollment in multi-dosing cohorts continues

Fusion also reported preclinical data showing the combination of FPI-1434 with olaparib resulting in synergistic efficacy against colorectal and lung cancer xenografts, and combination with immune checkpoint inhibitors demonstrated enhanced efficacy in colorectal cancer models

Data featured in oral sessions and posters at the SNMMI 2021 Virtual Annual Meeting

HAMILTON, Ontario and BOSTON, June 14, 2021 /PRNewswire/ -- Fusion Pharmaceuticals Inc. (NASDAQ:FUSN), a clinical-stage oncology company focused on developing next-generation radiopharmaceuticals as precision medicines, today announced the presentation of preliminary Phase 1 data from the single-dose portion of the study at theSociety of Nuclear Medicine and Molecular Imaging (SNMMI) Virtual Annual Meeting. The presentations and posters highlight the potential of Fusion's targeted alpha therapies (TATs) to enable delivery of alpha particle emitting isotopes (225Ac) to targeted tumor cells.