Benzinga | Jun 4, 2021 09:02AM EDT

Spectrum Pharmaceuticals Presents Poziotinib Data in Patients With Brain Metastases From ZENITH20 Clinical Trial At 2021 ASCO Annual Meeting

Spectrum Pharmaceuticals (NASDAQ:SPPI), a biopharmaceutical company focused on novel and targeted oncology therapies, today presented an e-poster on poziotinib CNS activity in patients with NSCLC with EGFR or HER2 exon 20 mutations. These data from Cohorts 1, 2 and 3 of the ongoing ZENITH20 clinical trial assessed the results from 36 patients with brain metastases at baseline with three patients (8%) achieving intracranial complete responses. The presentation titled "CNS activity of poziotinib in NSCLC with exon 20 insertion mutations" is available on the website for the 2021 ASCO Annual Meeting being held June 4-8, 2021.

"CNS metastases are a common and life-threatening complication of metastatic disease in NSCLC patients," said Francois Lebel, M.D., Chief Medical Officer of Spectrum Pharmaceuticals. "These data show clinically meaningful CNS activity for poziotinib treated NSCLC patients with CNS metastases with EGFR or HER2 exon 20 insertion mutations."