Benzinga | May 26, 2021 09:32AM EDT

Aptevo Stock Gains on Encouraging Single-Agent Activity for APVO436 In Leukemia Patients

* Aptevo Therapeutics Inc (NASDAQ:APVO) has announced positive results from Phase 1 dose-escalation trial evaluating lead ADAPTIR candidate, APVO436, for acute myeloid leukemia and myelodysplastic syndromes (AML/MDS).

* The study met its primary endpoint of identification of an active dose level for advanced studies.

* The Company plans to submit the data for publication later this year.

* Of seven evaluable relapsed AML patients treated in Cohort 6, four showed stabilization of their leukemias.

* Of those four patients with disease stabilization, three patients lived over 246 days, over 261 days, and over 281 days, respectively, and one progressed after a month.

* Two relapsed AML patients, who experienced stabilization of their leukemia, achieved partial remission and subsequently a complete remission.

* No partial or complete remissions have been observed at APVO436 dose levels either lower or higher than the Cohort 6 dose level.

* APVO436 was generally well tolerated and demonstrated a favorable side effect profile, including the absence of severe or prolonged neutropenia, an often serious condition associated with CD123-targeting therapies.

* Price Action: APVO shares are up 9.7% at $27.71 during the market session on the last check Wednesday.