Benzinga | May 4, 2021 07:38AM EDT

Cytokinetics Says Cohort 3 Of REDWOOD-HCM Is Open To Enrollment

Cytokinetics, Incorporated (NASDAQ:CYTK) today announced the opening of enrollment in Cohort 3 of REDWOOD-HCM (Randomized Evaluation of Dosing With CK-274 in Obstructive Outflow Disease in HCM), an ongoing Phase 2 clinical trial of CK-3773274 (CK-274), a next-generation cardiac myosin inhibitor in development for the potential treatment of hypertrophic cardiomyopathy (HCM). Cohort 3 will enroll patients whose background therapy includes disopyramide.



"After completing enrollment in the first two cohorts in REDWOOD-HCM, we are pleased to now begin Cohort 3, which is enrolling patients who are being treated with disopyramide," said Fady I. Malik, M.D., Ph.D., Cytokinetics' Executive Vice President of Research & Development. "Given that disopyramide is often prescribed in patients with more severe HCM, the data from Cohort 3 may support the potential use of CK-274 in a broader population of patients with obstructive HCM. Importantly, we do not believe that Cohort 3 is required to refine the dosing strategy that we expect to use in Phase 3 but it will help inform the inclusion criteria for that potentially pivotal clinical trial which we are planning to begin later this year."