Benzinga | May 3, 2021 08:11AM EDT

Homology Medicines Presents Data Demonstrating In Vivo Transduction of Non-Human Primate and Human Retinal Cells at ARVO Annual Meeting

Homology Medicines, Inc. (NASDAQ:FIXX), a clinical-stage genetic medicines company, announced today new preclinical data that demonstrated in vivo nuclease-free gene editing of retinal cells at the virtual Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting.

"For the first time, we have shown proof of principle in two gene targets that our AAVHSCs were able to transduce and edit human retinal cell types," stated Albert Seymour, Ph.D., Chief Scientific Officer of Homology Medicines. "We have now demonstrated through in vivo studies in NHPs that 11 of our capsids crossed the blood-retinal and blood-brain barriers, and the regional tropism of our capsids enables us to select those that are best suited to address retinal diseases. We believe our AAVHSCs have the potential to deliver one-time treatments for retinal diseases, and these data support further development of our ophthalmology program."