Benzinga | Apr 20, 2021 09:15AM EDT

Hoth Therapeutics Says Its mRNA Frame Shifting Therapeutic Exhibited 'highly positive' Results In Humanized Mast Cell Neoplasm Models

Hoth Therapeutics, Inc. (NASDAQ:HOTH), a patient-focused clinical-stage biopharmaceutical company, announced that its novel anti-cancer therapeutic exhibited highly positive results in humanized mast cell neoplasm models, representative in vitro and in vivo models for aggressive, mast cell-derived cancers such as mast cell leukemia and mast cell sarcoma. The anti-cancer therapeutic, which is currently in development, uses mRNA frame shifting that induces apoptosis of neoplastic mast cells.

These findings show that the novel anti-cancer therapeutic rapidly induces apoptosis and cell death in neoplastic mast cells. Furthermore, systemic administration of the anti-cancer therapeutic in an in vivo humanized mast cell neoplasm model showed a significant reduction in tumors and neoplastic mast cell infiltration from the therapeutic group compared to the vehicle control group. There were no obvious signs of toxicity in the study animals, suggesting that the novel anti-cancer therapeutic was well-tolerated.

Taken together, these data support that this targeted, anti-cancer therapeutic has the potential to be a game-changing therapy against mast cell-derived cancers. Hoth plans to pursue rapid development of this innovative therapeutic to support initiation of clinical trials. Further publication of these studies will be shared in manuscript form upon publication.