Benzinga | Apr 14, 2021 08:31AM EDT

I-Mab Announces Selected Poster Presentation Of CD73 Antibody Uliledlimab At American Society Of Clinical Oncology 2021 Annual Meeting

I-Mab (the "Company") (NASDAQ:IMAB), a clinical-stage biopharmaceutical company committed to the discovery, development and commercialization of novel biologics, today announced that its abstract on proprietary and highly differentiated CD73 antibody uliledlimab (also known as TJD5, or TJ004309) has been selected for detailed poster presentation at the 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, taking place virtually June 4-8, 2021.



Uliledlimab is a humanized CD73 antibody that works effectively as an anti-tumor agent through modulation of the tumor microenvironment by inhibiting the adenosine pathway that is implicated in tumor resistance to checkpoint immunotherapies. Uliledlimab is shown to strongly suppress tumor growth, especially when combined with a PD-(L)1 inhibitor, in pre-clinical studies. Uliledlimab interacts with a unique epitope involving a novel intra-dimer binding mode that enables its differentiated and favorable drug properties.

I-Mab presented a poster on the mechanistic findings underlying the differentiation, together with the preclinical research of uliledlimab, on April 10 at the 2021 American Association for Cancer Research (AACR) Annual Meeting.

I-Mab has made significant progress in the global clinical development of uliledlimab. In February 2021, I-Mab has completed the initial assessment of its U.S. clinical study investigating uliledlimab as a monotherapy lead-in followed by combination with atezolizumab (Tecentriq(r)) in patients with solid tumors. Topline results from the clinical study under contract with TRACON show that uliledlimab is safe and well tolerated at the dose range evaluated and demonstrate clinical activity in patients with advanced solid tumors.