Benzinga | Mar 31, 2021 08:32AM EDT

VolitionRx Limited Highlights Publication Of Nu.Q Capture Mass Spectrometry Paper

VolitionRx Limited (NYSE:VNRX) ("Volition"), a multi-national epigenetics company developing simple, easy to use, cost effective blood tests to help diagnose a range of cancers and other diseases in both humans and animals, announced today the publication in Scientific Reports of a paper entitled "A Novel Proteomics Approach to Epigenetic Profiling of Circulating Nucleosomes".

Dr. Marielle Herzog, lead author of the paper and Volition's Research and Development Director, commented, "Our novel method detects and quantifies histone modifications present in the circulating nucleosomes in the blood of cancer patients. We believe that our work has highlighted for the first time that histone H2A1R3 citrulline is, in plasma, upregulated in colorectal cancer patients and so could be a biomarker we target for future Nu.Q(r) immunoassay development. Furthermore, the use of Nu.Q(r) Capture may open up the possibility of using mass spectrometry not only for biomarker discovery but also as a high throughput platform for screening and/or diagnostics. It is also very good to see that this Nu.Q(r) Capture assay was found to be robust, reproducible and easy to use in laboratories in both the U.S. and Europe. Finally, we are delighted that our report was published in such a good impact factor journal."

Commenting on the publication Cameron Reynolds, Chief Executive Officer of Volition, said, "Nu.Q(r) Capture is one of Volition's four key pillars and this publication is another very important step forward for the company. I am extremely pleased that we continue to be on the very cutting edge of epigenetics, and aim for Nu.Q(r) Capture to be an important enabling technology in the liquid biopsy space. We believe the Nu.Q(r) Capture technology will be useful not only when used in combination with mass spectrometry to discover new biomarkers as per this paper, but also as a DNA enrichment technology which could aid diagnosis, treatment selection and treatment/ disease monitoring when used in combination with either sequencing and/or our Nu.Q(r) assays."

Please download the Paper here