Benzinga | Mar 22, 2021 01:16PM EDT

89bio's NASH Candidate Shows Clinically Meaningful Outcomes At ENDO Conference

89bio Inc (NASDAQ: ETNB) announced additional data from its Phase 1b/2a study evaluating BIO89-100 in patients with nonalcoholic steatohepatitis (NASH).

* The company will present the data at the Endocrine Society's annual meeting.

* BIO89-100 is a glycoPEGylated analog of FGF21.

* New analyses showed that BIO89-100 demonstrated clinically meaningful reductions in both liver fat volume and liver volume overall across all dosing groups.

* Liver volume reduced up to 15%, and liver fat volume decreased to 65% in treated patients at 13 weeks compared to baseline, as measured by magnetic resonance imaging-proton density fat fraction.

* These data extend the previously reported MRI-PDFF data in which BIO89-100 treatment resulted in up to 70% relative reduction in liver fat fraction relative to placebo treatment.

* Additionally, BIO89-100, as previously reported, demonstrated a favorable safety and tolerability profile, with rates of gastrointestinal side effects such as nausea, diarrhea, and vomiting similar to placebo.

* Price Action: ENTB shares were trading 3.8% higher at $26.04 in market trading hours on the last check Monday.