GlobeNewswire Inc | Dec 11, 2020 05:00AM EST

December 11, 2020

TR-1: Standard form for notification of major holdings

NOTIFICATION OF MAJOR HOLDINGS (to be sent to the relevant issuer and to theFCA in Microsoft Word format if possible)^i

1a. Identity of the issuer or the underlyingissuer of existing shares to which voting Amryt Pharma plcrights are attached^ii:1b. Please indicate if the issuer is a non-UK issuer (please mark with an ?X?if appropriate)Non-UK issuer 2. Reason for the notification (please mark the appropriate box or boxes withan ?X?)An acquisition or disposal of voting rights An acquisition or disposal of financial instruments XAn event changing the breakdown of voting rights Other (please specify)^iii: 3. Details of person subject to the notification obligation^ivName Stonepine Capital Management, LLCCity and country of registered office (if Bend, Oregon, USAapplicable)4. Full name of shareholder(s) (if different from 3.)^vName NACity and country of registered office (if applicable)5. Date on which the threshold was crossed or 08/12/2020reached^vi:6. Date on which issuer notified (DD/MM/YYYY): 10/12/20207. Total positions of person(s) subject to the notification obligation % of voting % of voting rights through Total of Total number rights attached financial both in % of voting to shares (total instruments (8.A + rights of of 8. A) (total of 8.B 1 8.B) issuer^vii + 8.B 2)Resulting situation onthe date on which NA 5.3% 5.3% 178,801,593threshold was crossedor reachedPosition of previousnotification (if NA NA NA applicable)

8. Notified details of the resulting situation on the date on which thethreshold was crossed or reached^viiiA: Voting rights attached to sharesClass/type Number of voting rights^ix % of voting rightsof Direct Indirect Direct Indirectshares (Art 9 of (Art 10 of (Art 9 of Directive (Art 10 ofISIN code Directive 2004/ Directive 2004/ 2004/109/EC) Directive(if 109/EC) 109/EC) (DTR5.1) 2004/109/EC)possible) (DTR5.1) (DTR5.2.1) (DTR5.2.1) SUBTOTAL 8. A

B 1: Financial Instruments according to Art. 13(1)(a) of Directive 2004/109/EC(DTR5.3.1.1 (a))Type of Exercise/ Number of voting rightsfinancial Expiration Conversion that may be acquired if % of votinginstrument date^x Period^xi the instrument is rights exercised/converted.ADS NA NA 9,402,010 5.3% SUBTOTAL 8. B 1 9,402,010 5.3%

B 2: Financial Instruments with similar economic effect according to Art. 13(1)(b) of Directive 2004/109/EC (DTR5.3.1.1 (b))Type of Expiration Exercise/ Physical or Number of voting % of votingfinancial date^x Conversion cash rights rightsinstrument Period ^xi settlement^xii SUBTOTAL 8.B.2

9. Information in relation to the person subject to the notification obligation(please mark theapplicable box with an ?X?)Person subject to the notification obligation is not controlledby any natural person or legal entity and does not control any other undertaking(s) holding directly or indirectly an interestin the (underlying) issuer^xiiiFull chain of controlled undertakings through which the votingrights and/or thefinancial instruments are effectively held starting with the Xultimate controlling natural person or legal entity^xiv (pleaseadd additional rows as necessary) % of voting rights if % of voting rights through Total of both if it equals or is financial instruments if it it equals or isName^xv higher than the equals or is higher than the higher than the notifiable threshold notifiable threshold notifiable thresholdJon M. NA 5.3% 5.3%PlexicoStonepineCapital NA 5.3% 5.3%Management,LLC Timothy P. NA 5.3% 5.3%LynchStonepineCapital NA 5.3% 5.3%Management,LLC

10. In case of proxy voting, please identify:Name of the proxy holder NAThe number and % of voting rights heldThe date until which the voting rights will be held

11. Additional information^xvi

Place of completion Bend, Oregon, USADate of completion 10/12/2020

Annex: Notification of major holdings (to be filed with the FCA only)

A: Identity of the person subject to the notification obligationFull name (including legal form for legal entities) Contact address (registered office for legal entities) E-Mail Phone number / Fax number Other useful information (at least legal representative for legal persons) B: Identity of the notifier, if applicableFull name Contact address E-Mail Phone number / Fax number Other useful information (e.g. functional relationship with the person or legal entity subject to the notification obligation)

C: Additional information

Please send the completed form together with this annex to the FCA at the following email address: Majorshareholdings@fca.org.uk. Please send in Microsoft Word format if possible.