Benzinga | Aug 20, 2020 06:46AM EDT

Annovis Bio Actively Recruiting Patients For Its Phase 2a Trials In Alzheimer's And Parkinson's Diseases

BERWYN, Pa., Aug. 20, 2020 (GLOBE NEWSWIRE) -- Annovis Bio Inc. (NYSE:ANVS), a clinical-stage drug platform company addressing Alzheimer's disease (AD), Parkinson's disease (PD) and other neurodegenerative diseases, is pleased to announce it has restarted patient recruitment for its Phase 2a clinical trial in AD which was suspended due to COVID-19 in March 2020, and initiated recruitment for its new Phase 2a clinical trial in AD and PD.



The Company's first Phase 2a trial of its lead compound, ANVS401, is a one-month study in 24 AD patients conducted in collaboration with the Alzheimer Disease Cooperative Study. The study is being conducted in six sites, including the University of California, San Diego, Johns Hopkins, Indiana University, Washington University, Cleveland Clinic, and Columbia University. Prior to suspension of enrollment, 14 patients had been enrolled and treated in this trial; patient 15 is expected to be enrolled at the end of August. Data from this trial is expected in 2021.

The second Phase 2a trial is a one-month study that will treat 14AD and 14 PD patients at 15 sites across the US. Initial data from this trial is expected in early 2021. This study will be followed by a dose response study in 40 PD patients, and the Company expects the final readout by late summer 2021.

"We are excited to be able to recruit patients for both of our Phase 2a trials," commented Maria Maccecchini, Ph.D., CEO of Annovis Bio. "We have increased the number of trial sites to expedite enrollment and to deliver on our projections as to when we would report data. We look forward to doing so as early as January 2021."

By fall, the Company also expects to report final data from its NIH-funded long-term toxicology studies, which should further confirm the safety of ANVS401 that has previously been demonstrated in Phase 1 and earlier toxicology studies.