PSTV
PLUS THERAPEUTICS, Inc. Common Stock
stock NASDAQ

SLS, INTS, or PSTV

Yep, mark my words. 2026 is PSTV's year and it will be a $3-$6 dollar stock by mid year

$PSTV ! 2026 is the year it will take off.

**Prepared:** December 25, 2025

**1. Executive Overview**
The next five years, from 2026 to 2031, are going to be defined by some serious bottlenecks in computing power, energy supplies, infrastructure strength, and digital systems. The real winners will be the companies that own and control these chokepoints; like cutting edge chips, reliable power generation, upgraded grids, secure data tools, and blockchain networks. Pulling together data from sources like Bloomberg, Yahoo Finance, TipRanks, ARK Invest, and various market outlooks, I'm eyeing a portfolio that could deliver substantial returns overall, with some AI and fintech picks potentially hitting over 300%.
This setup uses a barbell strategy: on one side, high upside bets for big potential gains; on the other, steady growers for reliability. I've thrown in 5–10% digital assets for extra diversification. Sure, there are risks; like chip shortages, policy changes in energy, or regulatory curveballs; but spreading things out and timing entries smartly should keep things in check. In this update, I've revisited some holdings I passed on before, focusing on their five year potential. If they show strong growth ahead, they're in, even if they don't fit the theme perfectly. I've added clear reasons for any exclusions too.

**2. Introduction**
The economy's shifting in big ways: rolling out AI means building massive infrastructure, energy needs are outpacing efficiency improvements, and decentralized finance is pushing for more control over digital assets. I've looked at over 50 stocks and a handful of cryptos using discounted cash flow models and valuation multiples. I've also factored in community feedback to broaden the view. The focus here is on future growth rather than sticking to strict boxes, so we can grab opportunities that cut across categories.
**3. Portfolio Allocation Framework**
**Sector Allocation (Target Weights)**
* AI & Compute: 30%
* Nuclear & Uranium: 25%
* Defense & Space: 15%
* Quantum & Speculative Tech: 10%
* Mega Cap Compounders: 15%
* Consumer Growth: 3%
* Income / Covered Calls: 2%
Compute and energy take the biggest slices because they're the core constraints everything else runs into.

**4. Risk vs. Return Positioning**
**Matrix:**
* **High Risk/High Return:** Quantum, space, biotech;these are tough to execute but could deliver 300%+ if they hit.
* **Medium Risk/High Return:** AI infrastructure, uranium, fintech;backed by solid demand.
* **Low Risk/Moderate Return:** Mega caps; reliable at 80–150%.
* **Low Risk/Income:** Steady yields for ballast.
This barbell setup builds toughness against market swings.

**5. Comprehensive Equity Portfolio Analysis**
I've tiered these by risk, then sorted within each by the highest potential returns (descending order), followed by my confidence level. The forecasts pull in some previously skipped picks: biotechs like PSTV, DRTS, ABVX, and SLS go to Tier 1 for their huge upside swings; fintechs like MSTR, APP, SOFI, AFRM, and PDD slot into Tier 2 or 3 for growth potential; and consumer play ELF lands in Tier 3 where it fits.

**5.1 Tier 1: Alpha Generators (High Asymmetry / High Risk)**
These are the disruptors;big swings possible, with biotech adds for those all or nothing catalysts.
|**Rank**|**Ticker**|**Company**|**Sector**|**Price ($)**|**2031 Est. ($)**|**Return (%)**|**Confidence**|**Growth Driver**|
|:-|:-|:-|:-|:-|:-|:-|:-|:-|
|1|PSTV|Plus Therapeutics|Biotech|0.55|7–22|1200–3900|85%|CNS cancer therapies; binary catalysts, strong analyst targets.|
|2|ABVX|Abivax|Biotech|138.35|2075–2767|1400–1900|80%|IBD trials; M&A potential.|
|3|RZLV|Rezolve AI|AI Commerce|2.8|11–14|300–400|90%|ARR surge; efficiency chokepoint.|
|4|CRWV|CoreWeave|AI Infra|80.26|369–401|360–415|80%|GPU dominance.|
|5|SLS|Sellas Life Sciences|Biotech|2.77|8–10|200–300|75%|Cancer immunotherapies; phase advancements.|
|6|IONQ|IonQ|Quantum|51.39|170–206|230–300|85%|Quantum lead.|
|7|ASTS|AST SpaceMobile|Space/Telecom|85.67|257–300|200–280|80%|Satellite monopoly.|
|8|DRTS|Alpha Tau Medical|Biotech|5.08|8–12|60–140|85%|Cancer therapy commercialization.|
|9|VKTX|Viking Therapeutics|Biotech|37|150–250 |305–575 |85%|Obesity market blockbuster potential.|
|10|NBIS|Nebius Group|AI Infra|90.03|225–315|150–250|85%|GPU clusters.|
|11|RCAT|Red Cat Holdings|Defense|9.18|23–32|150–250|80%|DoD drones.|
|12|QBTS|D Wave Quantum|Quantum|29.12|81–102|180–250|80%|Annealing systems.|
|13|QUBT|Quantum Computing Inc.|Quantum|11.73|33–41|180–250|80%|Photonic quantum.|
|14|POET|POET Technologies|AI Compute|7.15|21–26|200–275|80%|Photonic efficiency.|
|15|OKLO|Oklo Inc.|Nuclear|81.88|233–272|185–230|80%|SMR power.|
|16|RKLB|Rocket Lab|Space|77.18|170–232|120–200|80%|Launch duopoly.|
|17|LUNR|Intuitive Machines|Space|16.51|33–50|100–200|80%|Lunar logistics.|
|18|CAPC|Capstone Companies|Shell/RM |0.05 |0.20–1.00 |300–1900 |50%|OTC shell. Dilution risks high. |
**5.2 Tier 2: Structural Pillars (Infrastructure & Industry)**
These are the backbone plays; fintech adds bring in digital expansion.
|**Rank**|**Ticker**|**Company**|**Sector**|**Price ($)**|**2031 Est. ($)**|**Return (%)**|   **Confidence**|**Growth Driver**|
|:-|:-|:-|:-|:-|:-|:-|:-|:-|
|1|MSTR|MicroStrategy|Software/BTC|157.88|2842–11841|1700–7400|80%|BTC leverage; treasury strategy.|
|2|SOFI|SoFi Tech|Fintech|27.19|33–190|20–760|70%|Digital banking expansion.|
|3|APP|AppLovin|AdTech|728.45|839–2276|14–216|85%|AI ad optimization.|
|4|SYM|Symbotic|Robotics|58.84|179–218|205–270|85%|Automation backlog.|
|5|SOUN|SoundHound|AI Voice|11|33–44|200–300|85%|Voice adoption.|
|6|PLTR|Palantir|AI/Defense|194.13|582–679|200–250|80%|Analytics spine.|
|7|SERV|Serve Robotics|Robotics|10.86|29–43|170–300|80%|Delivery automation.|
|8|IREN|Iris Energy|AI Infra|42.07|120–139|185–233|80%|Renewable data centers.|
|9|APLD|Applied Digital|AI Infra|26.08|65–91|150–250|80%|HPC centers.|
|10|DRSHF|DroneShield Ltd|Defense/Drones|2.28|6-10|163–339|80%|Military Tech.|
|10|VRT|Vertiv|Data Center|166.26|346–394|108–138|85%|Cooling monopoly.|
|11|CCJ|Cameco|Uranium|93.41|196–226|110–145|90%|Supply deficit.|
|12|AFRM|Affirm|Fintech|75.64|48–157| 37–107|75%|BNPL growth.|
|13|CEG|Constellation Energy|Nuclear|361.33|698–797|93–121|85%|Baseload.|
|14|FIX|Comfort Systems USA|Grid/Infrastructre|958|1900–2900 |98–202 |80%|Electrical contractor for data centers |
|15|ITRI|Itron|Smart Grid|95.8|179–219|87–129|80%|Energy management.|
||AMPX|Amprius Technologies|Batteries/Energy |8.32|25–40 |201–381 |75%|Silicon anode batteries for EVs|
|16|GEV|GE Vernova|Grid|661.45|1197–1395|81–111|80%|Infrastructure.|
|17|UUUU|Energy Fuels|Uranium|15.18|32–37|110–145|85%|Spot upside.|
|18|UEC|Uranium Energy Corp.|Uranium|12.49|26–30|110–145|85%|Operational leverage.|
|29|SMR|NuScale Power|Nuclear|15.97|32–48|100–200|60%|Modular reactors.|
|20|QS|QuantumScape|Batteries|11.43|23–34|100–200|50%|Solid state.|
|21|ONDS|Ondas Holdings|IoT|8.96|18–27|100–200|80%|Networks.|
|22|BBAI|[BigBear.ai](http://BigBear.ai)|AI Analytics|6.12|12–18|100–200|75%|Defense.|
|23|NNE|NANO Nuclear|Nuclear|31.75|57–76|80–140|65%|Microreactors.|
|24|LEU|Centrus Energy|Nuclear|258.05|542–632|110–145|75%|Fuel.|
|25|URNM|Sprott Uranium Miners ETF|Uranium|56.51|119–138|110–145|80%|Diversified.|
**5.3 Tier 3: Stable Compounders (Mega Cap & Mature Tech)**
These are the reliable cash machines; consumer and media adds for consistent growth.
|**Rank**|**Ticker**|**Company**|**Sector**|**Price ($)**|**2031 Est. ($)**|**Return (%)**|   **Confidence**|**Growth Driver**|
|:-|:-|:-|:-|:-|:-|:-|:-|:-|
|1|ELF|e.l.f. Beauty|Consumer|78.46|643|720|80%|Brand penetration.|
|2|PDD|Pinduoduo|E commerce|112.06|166–349|48–212|75%|Global expansion.|
|3|NVDA|Nvidia|Semi/AI|189.21|378–473|100–160|90%|AI revenue.|
|4|TSLA|Tesla|EVs/AI|485.56|1117–1214|130–150|70%|Autonomy.|
|5|FLEX|Flex Ltd.|Manufacturing|63.74|127–159|100–150|80%|Hardware.|
|6|SNOW|Snowflake|Cloud|225.1|450–495|100–120|80%|Data.|
|7|MU|Micron|Semi|276.27|497–607|80–115|85%|HBM.|
|8|WDC|Western Digital|AI Storage/HDD|180|350–450|94–150|90%|Data center storage|
|9|AVGO|Broadcom|Semi|349.32|682–733|95–110|85%|ASICs.|
|10|AMZN|Amazon|Cloud/Retail|232.14|430–477|85–110|90%|AWS.|
|11|SMCI|Super Micro|Hardware|30.76|46–68|50–110|60%|Servers.|
|12|GOOGL|Alphabet|Tech/AI|314.35|581–628|85–100|90%|AI.|
|13|IBM|IBM|Tech|303.78|547–608|80–100|75%|Enterprise.|
|14|PL|Planet Labs|Satellite|20.73|31–41|50–100|80%|Geospatial.|
|15|TSM|TSMC|Semi|296.95|504–534|70–90|90%|Chips.|
|16|AMD|AMD|Semi|214.9|430–645|100–200|85%|AI chips.|
**5.4 Not Recommended Holdings**
I ran these through five year outlooks; the ones above made the cut for solid potential. Here's why these didn't, with specifics:
* **OKTA (Okta):** Fundamentals are decent, but Microsoft's push and a weakening moat mean less edge. Upside appears capped at 20–50% through 2031, with risks from market saturation; it resembles a mature defender rather than a dynamic leader. Forecasts suggest $107–134 by 2031.
* **PATH (UiPath):** RPA growth has slowed amid AI integration challenges and competition; forecasts suggest modest 50–100% upside to $24–32 by 2030, but with downside risks from execution misses. It lacks the explosive trajectory for compounding, positioning as a steady but unremarkable performer in a crowded field.
* **PARA (Paramount):** Streaming wars intensify, with content costs pressuring margins; projections indicate limited 50–100% growth to $17–22 by 2030, overshadowed by debt and acquisition uncertainties. It feels like a legacy media play struggling for relevance, not a high conviction compounder.
* **NFLX (Netflix):** Mature streaming market faces saturation, with rising content costs and competition from Disney, Amazon, and ad supported tiers eroding pricing power. Forecasts point to flat or modest growth, with total returns risking underperformance in a high growth portfolio; it looks like a stable but low upside incumbent amid shifting consumer habits.
**6. Digital Asset Outlook**
Allocating 5–10% here for diversification; sorted by maturity level.
|**Rank**|**Asset**|**Symbol**|**Current ($)**|**2031 Range ( $)**|**Upside (%)**|**Confidence**|**Rationale**|
|:-|:-|:-|:-|:-|:-|:-|:-|
|1|Bitcoin|BTC|88000|300k–710k|240–700|90%|Sovereign.|
|2|Ethereum|ETH|3065|10k–20k|226–550|85%|RWAs.|
|3|Solana|SOL|125|500–800|300–535|80%|DePIN.|
|4|Binance Coin|BNB|852|4k–6k|370–600|75%|Utility.|
|5|XRP|XRP|2.16|8–12|270–450|75%|Payments.|
|6|Cardano|ADA|0.36|2–3|455–730|70%|Partnerships.|
|7|Chainlink|LINK|8.00|25–40|210–400|65%|Interop.|
|8|Avalanche|AVAX|12.17|40–50|230–310|65%|Scaling.|
|9|TRON|TRX|0.33|1.70–2.10|415–530|50%|Stablecoins.|
|10|Toncoin|TON|2.50|6.00|140|55%|Integration.|
**7. Top 10 Overall Predictions (2026–2031)**
Mixing DCF models, analyst views, and portfolio projections, here's my ranked top 10 for the biggest upside plays. I prioritized the high end of return ranges, weighed by confidence and key drivers. These highlight the best shots at explosive growth, mixing AI constraints, biotech bets, fintech plays, and energy squeezes. Assumptions include steady macros, but I've baked in execution risks.
1. **MSTR (MicroStrategy):** Projected return 1700–7400%. As a leveraged Bitcoin play with a growing software base, MSTR stands out for its treasury strategy amplifying crypto adoption. Forecasts suggest $2842–11841 by 2031, driven by sovereign BTC inflows and premium expansion; high confidence (80%) in volatility fueled compounding.
2. **PSTV (Plus Therapeutics):** Projected return 1200–3900%. This biotech binary hinges on CNS cancer therapeutics breakthroughs, with phase advancements potentially unlocking M&A or commercialization. Estimates reach $7–22; strong analyst targets support 85% confidence, though clinical risks loom.
3. **ABVX (Abivax):** Projected return 1400–1900%. Late stage IBD trials position it for massive re rating, with efficacy data pointing to $2075–2767 valuations. 80% confidence reflects promising pipeline, but regulatory hurdles could cap upside.
4. **ELF (e.l.f. Beauty):** Projected return up to 720%. Brand loyalty and digital marketing dominance fuel unit economics, forecasting $643 by 2031. High velocity growth in consumer staples yields 80% confidence, resilient to cycles.
5. **CRWV (CoreWeave):** Projected return 360–415%. Dominant GPU cloud provider benefits from hyperscaler demand, estimating $369–401. 80% confidence in AI infra bottlenecks, with private to public transition as a catalyst.
6. **RZLV (Rezolve AI):** Projected return 300–400%. Micro cap AI commerce with 62% ARR growth implies re rating to $11–14. 90% confidence in execution, addressing efficiency chokepoints.
7. **SOUN (SoundHound):** Projected return 200–300%. Voice AI adoption in automotive and hospitality drives $33–44 estimates. 85% confidence from sector tailwinds, though competition persists.
8. **SYM (Symbotic):** Projected return 205–270%. Warehouse automation backlog (> $12B) positions it for $179–218, with 85% confidence in supply chain infra.
9. **IONQ (IonQ):** Projected return 230–300%. Trapped ion quantum leadership targets $170–206, with $1B revenue potential. 85% confidence in compute frontier breakthroughs.
10. **PLTR (Palantir):** Projected return 200–250%. Defense and commercial AI platform evolves to $582–679, with 80% confidence in embedded contracts and national security moats.
**8. Trading & Portfolio Management**
**8.1 Day Trading Watchlist (High Beta)**
For traders chasing swings, zero in on catalyst events. Beta measures a stock's volatility relative to the market;a beta over 1 means bigger ups and downs than the broader index, so expect sharper moves on news.
1. NVDA: Earnings, export updates (Beta \~2.3).
2. PLTR: Gov contracts (Beta \~1.5).
3. TSLA: FSD/reg approvals (Beta \~1.9).
4. SMCI: Backlog/audit news (Beta \~1.5).
5. RKLB: Launch successes (Beta \~2.2).
6. IONQ: Tech papers (Beta \~2.6).
7. QS: Battery trials (Beta \~2.8).
8. SOFI: Rate changes (Beta \~1.9).
9. OKLO: Reg milestones (Beta \~0.8).
10. SERV: Partner deals (Beta \~3.0).
11. ASTS: Satellite rolls (Beta \~2.8).
12. APP: Ad beats (Beta \~2.5).
13. MSTR: BTC moves (Beta \~3.4).
Watch for volume jumps intraday.
**8.2 Investment Tips & Risk Management**
* **Asset Allocation:** 60–70% in anchors like NVDA, AMZN, CCJ; 20–30% in upsiders like ASTS, OKLO, PSTV; 5–10% cryptos as inflation buffer.
* **Stop Losses:** Trail 10–12% on Tier 1; fix 5% on Tier 3.
* **Entry Indicators:** Buy on RSI under 35 daily; back with volume or MACD flips.
* **Rebalancing:** Yearly for beginners, $50–100 even per pick; quarterly for pros, trim over 15% weights. Stick to facts over hype; hedge with QQQI in flat times.
**9. Entry Zone Modeling & Capital Deployment Framework**
**Logic**
Buy fear, add on proof, skip peaks. The real advantage comes from going against the crowd: scoop up during fear sells (like macro drops), build slowly through chop, and own the infrastructure over flashy apps. This avoids traps like buying tops or panic selling lows, setting up for real compounding.
**9.1 Entry Zone Modeling by Ticker (High Conviction Subset)**
|**Ticker**|**Primary Buy Zone**|**Add On Zone (Confirmation)**|**Avoid Chasing When**|
|:-|:-|:-|:-|
|NVDA|20–30% pullback from ATH (macro/rate fear)|Stable earnings in corrections|Parabolic retail/ETF flows|
|TSM|15–25% geopolitical dips|Capex/node leadership|Risk fade sans reset|
|PLTR|RSI <40 post earnings|Revenue/margin expansion|Expansion without contracts|
|CCJ|Uranium spot weakness|Supply announcements|Spot >2SD spikes|
|UUUU|\>30% sentiment resets|Price regime shift|Retail squeezes|
|SMR|Regulatory delays|Milestone validation|Policy hype|
|OKLO|Timeline extensions|Hyperscaler wins|Narrative rallies|
|SMCI|Capex/margin panic|Backlog confirmation|Short covering|
|AMD|Underperformance vs NVDA|Inference inflection|Rotation peaks|
|QBTS|Event driven drops|Contract validation|Social pumps|
|APP|Ad market corrections|Efficiency gains|Hype cycles|
|MSTR|BTC drawdowns|Treasury additions|Pure BTC rallies|
|SOFI|Rate hike fears|User/profit inflections|Speculative surges|
**9.2 Sector Level Capital Deployment Heat Map (Illustrative)**
This visual guides where to put money first:
|**Sector**|**Allocation (%)**|**Rationale**|**Deployment Priority**|
|:-|:-|:-|:-|
|AI & Compute|30|Core bottlenecks in GPUs/power|High: Front load during dips|
|Nuclear & Uranium|25|Energy scarcity tailwinds|High: Accumulate on spot weakness|
|Defense & Space|15|Structural government spending|Medium: Add on contract news|
|Quantum / Speculative Tech|10|High upside optionality|Low: Size small, volatility based|
|Mega Cap Compounders|15|Cash flow anchors|Medium: Stabilize portfolio|
|Consumer Growth|3|Brand durability|Low: Opportunistic|
|Income|2|Yield preservation|Low: Hedge sideways markets|
Capital hits AI and nuclear first as must haves, then scales back for riskier stuff.
**9.3 Risk vs. Return Positioning Framework**
Mapping for balance:
|**Category**|**Examples**|**Risk Level**|**Return Potential**|**Role in Portfolio**|
|:-|:-|:-|:-|:-|
|High Risk/High Return|IONQ, ASTS, PSTV|High (execution/binary)|300%+|Asymmetry drivers; 20–30% allocation|
|Medium Risk/High Return|PLTR, CCJ, MSTR|Medium (demand visibility)|150–300%|Core growth; 40–50%|
|Low Risk/Moderate Return|NVDA, AMZN, TSM|Low (market dominance)|80–150%|Anchors; 20–30%|
|Low Risk/Income|QQQI, ELF|Low (yields/dividends)|50–100%|Stabilizers; 5–10%|
Supports the barbell: swings on one side, steadiness on the other.
**10. Risk Management & Execution Notes**
* **Rebalancing:** Yearly to reset weights, sell overages (>20% shift) when strong.
* **Sizing:** Limit speculation to 2–5% based on volatility (beta >2.0 gets smaller).
* **Overexposure Avoidance:** Cap any theme (e.g., AI) at 40%; mix regions.
* **Infrastructure Focus:** Let energy/compute lead; check macros (rates, geopolitics) quarterly.
* **Drawdown Prep:** Keep 10% cash for deals; collar options on volatiles.

**Note:** The brokerage I use gives out free stocks and 8.1% APY on uninvested funds. Message me for info.

**P.S.** *I've earned two university degrees. I completed all of the research myself and this is all hand typed. This report reflects personal research and synthesis, supported by external AI tools for organization and error‑checking. T*he stated “confidence” percentages should be interpreted cautiously. *It is not financial advice. Do your own homework and make decisions based on your own risk tolerance and objectives.*